Sleep and Rhythms Projects

Post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) Hepatic Encephalopathy-A Review of the Past Decade’s Literature Focusing on Incidence, Risk Factors, and Prophylaxis

Friis KH, Thomsen KL, Laleman W, Montagnese S, Vilstrup H, Lauridsen MM J Clin Med Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for portal hypertension and its’ complications in liver cirrhosis, yet the development of hepatic encephalopathy (HE) remains a significant concern. This review covers the reported incidence, risk factors, and management strategies […]

A PDZ scaffolding/CaM-mediated pathway in Cryptochrome signaling

Bellanda M, Damulewicz M, Zambelli B, Costanzi E, Gregoris F, Mammi S, Tosatto SCE, Costa R, Minervini G, Mazzotta GM Protein Sci Cryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated […]

Managing Circadian Disruption due to Hospitalization: A Pilot Randomized Controlled Trial of the CircadianCare Inpatient Management System

Mangini C, Zarantonello L, Formentin C, Giusti G, Domenie ED, Ruggerini D, Costa R, Skene DJ, Basso D, Battagliarin L, Di Bella A, Angeli P, Montagnese S J Biol Rhythms The objective of the present study was to test the effects of an inpatient management system (CircadianCare) aimed at limiting the negative impact of hospitalization […]

The Alarm Clock Against the Sun: Trends in Google Trends Search Activity Across the Transitions to and from Daylight Saving Time

Domenie ED, Zarantonello L, Mangini C, Formentin C, Giusti G, Ruggerini D, Cusumano P, Biscontin A, Costa R, Montagnese S J Circadian Rhythms The human circadian timing system depends on the light/dark cycle as its main cue to synchronize with the environment, and thus with solar time. However, human activities depend also on social time, […]

Driving fatigue increases after the Spring transition to Daylight Saving Time in young male drivers: A pilot study

Orsini F, Giusti G, Zarantonello L, Costa R, Montagnese S, Rossi R Transportation Research Part F: Traffic Psychology and Behaviour The Spring transition to Daylight Saving Time (DST) has been associated with several health and road safety issues. Previous literature has focused primarily on the analysis of historical crash and hospitalization data, without investigating specific […]

Working Memory in Patients with Varying Degree of Hepatic Encephalopathy (HE): A Pilot EEG-fNIRS Study

Zarantonello L, Mangini C, Erminelli D, Fasolato S, Angeli P, Amodio P & Montagnese S Neurochem Res It is known that patients with covert hepatic encephalopathy (CHE) exhibit working memory abnormalities, but to date there is no study comparing patients with cirrhosis with/without CHE and controls with both electrophysiological and hemodynamic data collected at the […]