Sleep and Rhythms Projects

Driving simulator performance worsens after the Spring transition to Daylight Saving Time

Orsini F, Zarantonello L, Costa R, Rossi R, Montagnese S iScience Circadian desynchrony and sleep deprivation related to the Spring transition to Daylight Saving Time (DST) have been associated with several unfavorable outcomes, including an increase in road traffic accidents. As previous work has mainly focused on analyzing historical crash/hospitalization data, there is virtually no literature […]

Hepatic encephalopathy

Häussinger D, Dhiman RK, Felipo V, Görg B, Jalan R, Kircheis G, Merli M, Montagnese S, Romero-Gomez M, Schnitzler A, Taylor-Robinson SD, Vilstrup H Nat Rev Dis Primers Illustrated summary of the article Full text

Mitochondrial Cytochrome c Oxidase Defects Alter Cellular Homeostasis of Transition Metals

Brischigliaro M, Badocco D, Costa R, Viscomi C, Zeviani M, Pastore P, Fernández-Vizarra E Front Cell Dev Biol The redox activity of cytochrome c oxidase (COX), the terminal oxidase of the mitochondrial respiratory chain (MRC), depends on the incorporation of iron and copper into its catalytic centers. Many mitochondrial proteins have specific roles for the synthesis and […]

Toward a Molecular Approach to Chronotype Assessment

Biscontin A, Zarantonello L, Russo A, Costa R, Montagnese R J Biol Rhythms The aim of the present study was to develop a Polygenic Score-based model for molecular chronotype assessment. Questionnaire-based phenotypical chronotype assessment was used as a reference. In total, 54 extremely morning/morning (MM/M; 35 females, 39.7 ± 3.8 years) and 44 extremely evening/evening […]

A Circadian Hygiene Education Initiative Covering the Pre-pandemic and Pandemic Period Resulted in Earlier Get-Up Times in Italian University Students: An Ecological Study

Montagnese S, Zarantonello L, Formentin C, Giusti G, Mangini C, Isherwood CM, Ferrari P, Paoli A, Mapelli D, Rizzuto R, Toppo S, Skene DJ, Vettor R, Costa R Front Neurosci The aims of the present study were to obtain sleep quality and sleep timing information in a group of university students and to evaluate the […]

Editorial: Entrainment of Biological Rhythms

Costa R, Kyriacou C Front Physiol Circadian rhythms are ubiquitous and are observed in nearly all organisms that have been studied which inhabit our planet. These include animals, plants, fungi as well as some bacteria. These endogenous clocks will tick along nicely with an approximately 24 h period in constant conditions because they are generated […]

New Therapies of Liver Diseases: Hepatic Encephalopathy

Mangini C, Montagnese S J Clin Med Hepatic encephalopathy (HE) is a common complication of advanced liver disease which has profound implications in terms of the patients’ ability to fulfil their family and social roles, to drive and to provide for themselves. Recurrent and persistent HE is still a serious management challenge, translating into a […]