Special Issue: Pathophysiology, diagnosis, and management of hepatic encephalopathy
Montagnese S, Lauridsen MM Metab Brain Dis No abstract available Full text
Editorial: Translational and clinical chronobiology
Facer-Childs ER, Kim M, Montagnese S Front Physiol No abstract available Full text
Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE
Chaganti J, Zeng G, Tun N, Lockart I, Abdelshaheed C, Cysique L, Montagnese S, Brew BJ, Danta M HE Hepatol Commun Background: Using dynamic contrast-enhanced (DCE) MR perfusion and MR spectroscopy this study aimed to characterize the blood-brain barrier permeability and metabolite changes in patients with cirrhosis and without covert HE. Methods: Covert HE was defined using […]
An isolated insular stroke mimics a bout of overt hepatic encephalopathy in a patient with cirrhosis
Mangini C, Gagliardi R, Causin F, Angeli P, Montagnese S J Hepatol No abstract available Full text
Prevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study
Gairing SJ, Mangini C, Zarantonello L, Gioia S, Nielsen EJ, Danneberg S, Gabriel M, Ehrenbauer AF, Bloom PP, Ripoll C, Sultanik P, Galle PR, Labenz J, Thabut D, Zipprich A, Lok AS, Weissenborn K, Marquardt JU, Lauridsen MM, Nardelli S, Montagnese S, Labenz C Am J Gastroenterol Introduction: The prevalence of minimal hepatic encephalopathy (MHE), in […]
Prognosis and Survival Modelling in Cirrhosis Using Parenclitic Networks
Zhang H, Oyelade T, Moore KP, Montagnese S, Mani AR Front Netw Physiol Background: Liver cirrhosis involves multiple organ systems and has a high mortality. A network approach to complex diseases often reveals the collective system behaviours and intrinsic interactions between organ systems. However, mapping the functional connectivity for each individual patient has been challenging due […]
Natural alleles of the clock gene timeless differentially affect life-history traits in Drosophila
Andreatta G, Montagnese S, Costa R Front Physiol Circadian clocks orchestrate a variety of physiological and behavioural functions within the 24-h day. These timekeeping systems have also been implicated in developmental and reproductive processes that span more (or less) than 24 h. Whether natural alleles of cardinal clock genes affect entire sets of life-history traits […]
Circadian rhythms and the liver
Costa R, Mangini C, Domenie E, Zarantonello L, Montagnese S Liver Int This narrative review briefly describes the mammalian circadian timing system, the specific features of the liver clock, also by comparison with other peripheral clocks, the role of the liver clock in the preparation to food intake, and its relationship with energy metabolism. It […]
Keeping an eye on circadian time in clinical research and medicine
Klerman EB, Brager A, Carskadon MA, Depner CM, Foster R, Goel N, Harrington M, Holloway PM, Knauert MP, LeBourgeois MK, Lipton J, Merrow M, Montagnese S, Ning M, Ray D, Scheer FAJL, Shea SA, Skene DJ, Spies C, Staels B, St-Onge MP, Tiedt S, Zee PC, Burgess HJ Clin Transl Med Background: Daily rhythms are […]
Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker
Granados-Fuentes D, Cho K, Patti GJ, Costa R, Herzog E D, Montagnese S Liver Int Patients with cirrhosis exhibit features of circadian disruption. Hyperammonaemia has been suggested to impair both homeostatic and circadian sleep regulation. Here, we tested if hyperammonaemia directly disrupts circadian rhythm generation in the central pacemaker, the suprachiasmatic nuclei (SCN) of the […]