Sleep and Rhythms Projects

Altered blood-brain barrier permeability is associated with abnormal distant connectivity and regional homogeneity in covert hepatic encephalopathy – a cross sectional study

Chaganti J, Zeng G, Patil A, Lockart I, Dellalana M, Montagnese S, Brew B, Danta M Hepatology Background: Covert hepatic encephalopathy (CHE) is clinically underrecognized. Using MRI, we explored the relationship between functional connectivity as a marker of executive dysfunction and the blood-brain barrier permeability marker KTRANS in a cross-sectional cohort of covert HE (CHE), no […]

Hepatic encephalopathy-We are no longer those who believe that reality is what we perceive

Montagnese S, Duarte-Rojo A Hepatology Full Text

Stuck in time: The slow march of circadian medicine and how to speed it up

Cajochen C, Montagnese S J Sleep Res While there is considerable enthusiasm for the translational and clinical applications of chronobiology, their actual implementation is not progressing as rapidly as might be expected. Here we discuss the possibility that this may relate to a combination of conceptual, methodological, evidentiary and training challenges. These are compounded by […]

Potential bidirectional communication between the liver and the central circadian clock in MASLD

Gachon F, Bugianesi E, Castelnuovo G, Oster H, Pendergast JS, Montagnese S NPJ Metab Health Dis Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. […]

Activation of the kynurenine pathway identified in individuals with covert hepatic encephalopathy

Zeng G, Krishnamurthy S, Staats Pires A, Guller A, Chaganti J, Tun N, Lockart I, Montagnese S, Brew B, Guillemin GJ, Danta M, Heng B Hepatol Commun Background: HE is a neuropsychiatric complication of liver disease characterized by systemic elevation in ammonia and proinflammatory cytokines. These neurotoxins cross the blood-brain barrier and cause neuroinflammation, which can […]

End-procedural adherence to recommended hemodynamic targets does not improve the outcome of elective TIPS in patients with cirrhosis

Roccarina D, Saltini D, Adotti V, Rosi M, Senzolo M, Nardelli S, Bianchini M, Biribin L, Caporali C, Margherita F, Ragozzino L, Guasconi T, Casari F, Gioia S, Campani C, Prampolini F, Ingravallo A, Gitto S, Aspite S, Arena U, Citone M, Gaggini M, Ridola L, Barbiero G, De Masi S, Riggio O, Merli M, […]

Sleep timing in flies from “adolescence” to adulthood

Domenie ED, Cusumano P, Montagnese S, Costa R Fly (Austin) The aim of the present study was to assess sleep timing in Drosophila melanogaster at different ages, within the setting of an enforced schedule of varying light-dark stimuli, simulating light exposure variations between four typical office working days and one free day spent outside by a human, for a total of […]

Validation and TaqMan Conversion of a Molecular Chronotype Assessment Approach

Biscontin A, Russo A, Marnetto D, Pagani L, Costa R, Montagnese S J Biol Rhythms The present study aimed to develop a TaqMan genotyping card for molecular chronotype assessment based on a predictive panel of 35 previously identified genetic variants. A reliable TaqMan assay was successfully developed for 33 out of the 35 chronotype-predictive variants. […]

Assessing evidence in translational chronobiology: The cases of Daylight Saving Time and road safety, and of school start times and sleep duration

Giusti G, Mangini C, Erminelli D, Domenie ED, Montagnese S Chronobiology International One of the main challenges in translating chronobiology research into clinical practice is represented by differences in how basic scientists and clinicians evaluate evidence. The workshop “Assessing Evidence in Translational Chronobiology,” which was held at the University of Surrey in June 2023, addressed […]

Electrophysiological and hemodynamic mechanisms underlying load modulations in visuospatial working memory: A functional near-infrared spectroscopy (fNIRS) and electroencephalogram (EEG) study

Zarantonello L, Brigadoi S, Schiff S, Bisiacchi PS, Cutini S, Montagnese S, Amodio P Behav Neurosci The n-back task has been widely used to study working memory. Previous studies investigating the electrophysiological (electroencephalogram [EEG]) and hemodynamic correlates (functional near-infrared spectroscopy [fNIRS]) of the n-back task have been generally based on verbal stimuli and only investigated […]