Category Archives: Liver-brain Axis

Application of short-term analysis of skin temperature variability in prediction of survival in patients with cirrhosis

Abid NU, Lum Cheng In T, Bottaro M, Shen X, Hernaez Sanz I, Yoshida S, Formentin C, Montagnese S, Mani AR Front Netw Physiol Background: Liver cirrhosis is a complex disorder, involving several different organ systems and physiological network disruption. Various physiological markers have been developed for survival modelling in patients with cirrhosis. Reduction in heart […]

Post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) Hepatic Encephalopathy-A Review of the Past Decade’s Literature Focusing on Incidence, Risk Factors, and Prophylaxis

Friis KH, Thomsen KL, Laleman W, Montagnese S, Vilstrup H, Lauridsen MM J Clin Med Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for portal hypertension and its’ complications in liver cirrhosis, yet the development of hepatic encephalopathy (HE) remains a significant concern. This review covers the reported incidence, risk factors, and management strategies […]

Working Memory in Patients with Varying Degree of Hepatic Encephalopathy (HE): A Pilot EEG-fNIRS Study

Zarantonello L, Mangini C, Erminelli D, Fasolato S, Angeli P, Amodio P & Montagnese S Neurochem Res It is known that patients with covert hepatic encephalopathy (CHE) exhibit working memory abnormalities, but to date there is no study comparing patients with cirrhosis with/without CHE and controls with both electrophysiological and hemodynamic data collected at the […]

Novel magnetic resonance KTRANS measurement of blood-brain barrier permeability correlated with covert HE

Chaganti J, Zeng G, Tun N, Lockart I, Abdelshaheed C, Cysique L, Montagnese S, Brew BJ, Danta M HE Hepatol Commun Background: Using dynamic contrast-enhanced (DCE) MR perfusion and MR spectroscopy this study aimed to characterize the blood-brain barrier permeability and metabolite changes in patients with cirrhosis and without covert HE. Methods: Covert HE was defined using […]