Category Archives: Liver-brain Axis

Overt Hepatic Encephalopathy: More Than Meets the Eye

Erminelli D, Mangini C, Zarantonello L, Angeli P, Montagnese S Am J Gastroenterol Introduction: We aimed to assess the reliability of a qualitative approach to overt hepatic encephalopathy (OHE) diagnosis compared with the semiquantitative, and recommended one. Methods: The above 2 methods were compared in 411 outpatients (71% males, 60 ± 10 years, model for end-stage liver […]

Application of short-term analysis of skin temperature variability in prediction of survival in patients with cirrhosis

Abid NU, Lum Cheng In T, Bottaro M, Shen X, Hernaez Sanz I, Yoshida S, Formentin C, Montagnese S, Mani AR Front Netw Physiol Background: Liver cirrhosis is a complex disorder, involving several different organ systems and physiological network disruption. Various physiological markers have been developed for survival modelling in patients with cirrhosis. Reduction in heart […]

Post-Transjugular Intrahepatic Portosystemic Shunt (TIPS) Hepatic Encephalopathy-A Review of the Past Decade’s Literature Focusing on Incidence, Risk Factors, and Prophylaxis

Friis KH, Thomsen KL, Laleman W, Montagnese S, Vilstrup H, Lauridsen MM J Clin Med Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for portal hypertension and its’ complications in liver cirrhosis, yet the development of hepatic encephalopathy (HE) remains a significant concern. This review covers the reported incidence, risk factors, and management strategies […]

Working Memory in Patients with Varying Degree of Hepatic Encephalopathy (HE): A Pilot EEG-fNIRS Study

Zarantonello L, Mangini C, Erminelli D, Fasolato S, Angeli P, Amodio P & Montagnese S Neurochem Res It is known that patients with covert hepatic encephalopathy (CHE) exhibit working memory abnormalities, but to date there is no study comparing patients with cirrhosis with/without CHE and controls with both electrophysiological and hemodynamic data collected at the […]