Novel molecular tools to estimate circadian indices in population health and in the clinical setting

Managing sleep-wake disruption due to hospitalization: the CircadianCare project

Metabolic chronobiology: mitochondrial metabolism and seasonality in model organisms

Skin temperature and sleep-wake patterns in health and disease

Functional and molecular characterization of genes involved in mitochondrial diseases in model organisms

Educational interventions for the management of sleep-wake timing abnormalities in young adults.

Genetic basis of diurnal preference and fluctuations in vigilance and mood over the 24 hours

Chronotherapy for sleep-wake disturbances in patients with liver disease and dementing disorders

Epigenetic modifications induced by chronic disruption of the circadian clock in Drosophila

Ad-hoc diagnostic tools and protocols for medical patients with circadian disorders

Chronotype, circadian desynchrony and driving performance

Identification of pathways modulating sleep duration, from genomics to transcriptomics

SLEEP & RHYTMS IN MEDICINE for medical students.

Students learn a set of core concepts and then attend a series of practicals in which they are welcome to test sleep-wake questionnaires, actigraphs, a polysomnography machine, temperature sensors and other relevant tools. The course started in academic year 2015-2016 and was opened by Professor Debra Skene (UK), past President of European Biological Rhythms Society.

Learn more


NEUROBIOLOGY for the Master's in Molecular Biology.

Students learn about the neurogenetic bases of circadian rhythmicity, and the functional organization of the biological clock in model organisms, including humans. In addition, they learn about mechanisms of clock synchronisation and about the consequences of desynchronisation/misalignment. Practicals include genotyping for clock gene polymorphisms, definition of chronotype and direct experience of the effects of morning light administration on sleep-wake patterns and melatonin urinary metabolites.

Learn more