Cryptochrome Is a Regulator of Synaptic Plasticity in the Visual System of Drosophila melanogaster
Damulewicz M, Mazzotta GM, Sartori E, Rosato E, Costa R, Pyza EM Frontiers in Molecular Neuroscience, 2017 Drosophila CRYPTOCHROME (CRY) is a blue light sensitive protein with a key role in circadian photoreception. A main feature of CRY is that light promotes an interaction with the circadian protein TIMELESS (TIM) resulting in their ubiquitination and degradation, a […]
Calmodulin Enhances Cryptochrome Binding to INAD in Drosophila Photoreceptors.
Mazzotta GM, Bellanda M, Minervini G, Damulewicz M, Cusumano P, Aufiero S, Stefani M, Zambelli B, Mammi S, Costa R, Tosatto SCE. Frontiers in Molecular Neuroscience, 2018 Light is the main environmental stimulus that synchronizes the endogenous timekeeping systems in most terrestrial organisms. Drosophila cryptochrome (dCRY) is a light-responsive flavoprotein that detects changes in light […]
Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.
Cusumano P, Biscontin A, Sandrelli F, Mazzotta GM, Tregnago C, De Pittà C, Costa R. Plos Genetics Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circadian behaviour by misexpressing it within […]
Cryptochrome Interacts With Actin and Enhances Eye-Mediated Light Sensitivity of the Circadian Clock in Drosophila melanogaster.
Schlichting M, Rieger D, Cusumano P, Grebler R, Costa R, Mazzotta GM, Helfrich-Förster C. Frontiers in Molecular Neuroscience Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of […]
Changes in Accident & Emergency Visits and Return Visits in Relation to the Enforcement of Daylight Saving Time and Photoperiod
Ferrazzi E., Romualdi C., Ocello M., Frighetto G., Turco M.,Vigolo S., Fabris F., Angeli P.,Vettore G., Costa R., Montagnese S. Journal of Biological Rhythms Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome […]