A low-cost, user-friendly electroencephalographic recording system for the assessment of hepatic encephalopathy.

Schiff S, Casa M, Di Caro V, Aprile D, Spinelli G, De Rui M, Angeli P, Amodio P, Montagnese S. Hepatology. 2016 Electroencephalography (EEG) is useful to objectively diagnose/grade hepatic encephalopathy (HE) across its spectrum of severity. However, it requires expensive equipment, and hepatogastroenterologists are generally unfamiliar with its acquisition/interpretation. Recent technological advances have led to the development […]

Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels.

Green EW, O’Callaghan EK, Hansen CN, Bastianello S, Bhutani S, Vanin S, Armstrong JD, Costa R, Kyriacou CP. Proceeding of the National Academy of Sciences Abstract Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and evening (E) locomotor activity and a “siesta” in the […]

Period and timeless mRNA Splicing Profiles under Natural Conditions in Drosophila melanogaster.

Montelli S, Mazzotta G, Vanin S, Caccin L, Corrà S, De Pittà C, Boothroyd C, Green EW, Kyriacou CP, Costa . Journal of biological rhythms Abstract Previous analysis of Drosophila circadian behavior under natural conditions has revealed a number of novel and unexpected features. Here we focus on the oscillations of per and tim mRNAs […]

Assessment of 6-sulfatoxymelatonin rhythms and melatonin response to light in disease states: lessons from cirrhosis.

Montagnese S, Middleton B, Corrias M, Mani AR, Skene DJ, Morgan MY. Chronobiology International Abstract Circadian rhythmicity and non-visual sensitivity to light can be assessed, in healthy subjects, by measuring the rhythm of the urinary melatonin metabolite 6-sulphatoxymelatonin (aMT6s) and by determining the response of plasma melatonin to nocturnal retinal light exposure, respectively. However, the […]

Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock.

Bee L, Marini S, Pontarin G, Ferraro P, Costa R, Albrecht U, Celotti L. Nucleic Acids Research Abstract The efficiency of Nucleotide Excision Repair (NER)process is crucial for maintaining genomic integrity because in many organisms, including humans, it represents the only system able to repair a wide range of DNA damage. The aim of the […]