Unexpected features of Drosophila circadian behavioural rhythms under natural conditions.
Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP. Nature Abstract Circadian clocks have evolved to synchronize physiology, metabolism and behaviour to the 24-h geophysical cycles of the Earth. Drosophila melanogaster’s rhythmic locomotor behaviour provides the main phenotype for the identification of higher eukaryotic clock genes. […]
Induced hyperammonemia may compromise the ability to generate restful sleep in patients with cirrhosis.
Bersagliere A, Raduazzo ID, Nardi M, Schiff S, Gatta A, Amodio P, Achermann P, Montagnese S. Hepatology Abstract In patients with cirrhosis, hyperammonemia and hepatic encephalopathy are common after gastrointestinal bleeding and can be simulated by an amino acid challenge (AAC), or the administration of a mixture of amino acids mimicking the composition of hemoglobin. […]