Hepatic encephalopathy 2018: A clinical practice guideline by the Italian Association for the Study of the Liver (AISF)
Sara Montagnese,Francesco Paolo Russo, Piero Amodio, Patrizia Burra, Antonio Gasbarrini, Carmela Loguercio, Giulio Marchesini, Manuela Merli, Francesca Romana Ponziani, Oliviero Riggio, Carmelo Scarpignato Digestive and Liver Disease Hepatic encephalopathy (HE) is a common, worrisome and sometimes difficult to manage complication of end-stage liver disease. HE is often recurrent, requiring multiple hospital admissions. It can have […]
Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study
Matteo Turco, Nora Cazzagon, Irene Franceschet, Chiara Formentin, Giovanni Frighetto, Francesca Giordani, Nicola Cellini, Gabriella Mazzotta, Rodolfo Costa, Benita Middleton, Debra J. Skene, Annarosa Floreani and Sara Montagnese Frontiers in Physiology Patients with Primary Biliary Cholangitis (PBC) exhibit delayed sleep-wake habits, disturbed night sleep and daytime sleepiness/fatigue. Such combination of symptoms is reminiscent of delayed […]
Cryptochrome Is a Regulator of Synaptic Plasticity in the Visual System of Drosophila melanogaster
Damulewicz M, Mazzotta GM, Sartori E, Rosato E, Costa R, Pyza EM Frontiers in Molecular Neuroscience, 2017 Drosophila CRYPTOCHROME (CRY) is a blue light sensitive protein with a key role in circadian photoreception. A main feature of CRY is that light promotes an interaction with the circadian protein TIMELESS (TIM) resulting in their ubiquitination and degradation, a […]
Calmodulin Enhances Cryptochrome Binding to INAD in Drosophila Photoreceptors.
Mazzotta GM, Bellanda M, Minervini G, Damulewicz M, Cusumano P, Aufiero S, Stefani M, Zambelli B, Mammi S, Costa R, Tosatto SCE. Frontiers in Molecular Neuroscience, 2018 Light is the main environmental stimulus that synchronizes the endogenous timekeeping systems in most terrestrial organisms. Drosophila cryptochrome (dCRY) is a light-responsive flavoprotein that detects changes in light […]
Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster.
Cusumano P, Biscontin A, Sandrelli F, Mazzotta GM, Tregnago C, De Pittà C, Costa R. Plos Genetics Single microRNAs are usually associated with hundreds of putative target genes that can influence multiple phenotypic traits in Drosophila, ranging from development to behaviour. We investigated the function of Drosophila miR-210 in circadian behaviour by misexpressing it within […]