Blood metabolomics undercovers inflammation-associated mitochondrial dysfunction as a potentian mechanism underlying ACLF
Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot c, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin H, Hautbergue […]
A meta-analysis of magnetic resonance spectroscopy in the diagnosis of hepatic encephalopathy
Zeng G, Penninkilampi R, Chaganti J, Montagnese S, Brew BJ, Danta M Neurology Objective Various imaging modalities have been used to explore pathogenic mechanisms and stratify the severity of hepatic encephalopathy (HE). The hypothesis of this meta-analysis was that there is a progressive identifiable derangement of imaging measures using magnetic resonance spectroscopy (MRS) related to the […]
Effect of Morning Light Glasses and Night Short-Wavelength Filter Glasses on Sleep-Wake Rhythmicity in Medical Inpatients
Formentin C, Carraro S, Turco M, Zarantonello L, Angeli P, Montagnese S Frontiers in physiology Sleep and circadian rhythm disorders are common amongst medical inpatients. They are caused by a mixture of factors, including noise, loss of habitual daily routines, and abnormal exposure to light, which tends to be insufficient in the day and too […]
Clinical, neuropsychological and neurophysiological indices and predictors of hepatic encephalopathy (HE)
Formentin C, Zarantonello L, Mangini C, Frigo A C, Montagnese S, Merkel C Liver International Background and Aims The occurrence of overt hepatic encephalopathy (HE) marks a significant progression in the natural history of liver disease. The aims of the present study were to: 1) describe a large cohort of patients with cirrhosis in terms […]
Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction
Von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da-Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E Life Science Alliance Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for […]