Molecular Organism – Page 3

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. J Biol Rhythms. 2017 The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may […]

Identifying pathways modulating sleep duration: from genomics to transcriptomics

Allebrandt K, Teder-Laving M, Cusumano P, Frishman G, Levandovski R, Ruepp A, Hidalgo M, Costa R, Metspalu A, Roenneberg T, de Pittà C. Scientific Reports Recognizing that insights into the modulation of sleep duration can emerge by exploring the functional relationships among genes, we used this strategy to explore the genome-wide association results for […]

KrillDB: A de novo transcriptome database for the Antarctic krill (Euphausia superba).

Sales G, Deagle BE, Calura E, Martini P, Biscontin A, De Pittà C, Kawaguchi S, Romualdi C, Meyer B, Costa R, Jarman S. PLoS One Abstract Antarctic krill (Euphausia superba) is a key species in the Southern Ocean with an estimated biomass between 100 and 500 million tonnes. Changes in krill population viability would have […]

Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels.

Green EW, O’Callaghan EK, Hansen CN, Bastianello S, Bhutani S, Vanin S, Armstrong JD, Costa R, Kyriacou CP. Proceeding of the National Academy of Sciences Abstract Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and evening (E) locomotor activity and a “siesta” in the […]

Period and timeless mRNA Splicing Profiles under Natural Conditions in Drosophila melanogaster.

Montelli S, Mazzotta G, Vanin S, Caccin L, Corrà S, De Pittà C, Boothroyd C, Green EW, Kyriacou CP, Costa . Journal of biological rhythms Abstract Previous analysis of Drosophila circadian behavior under natural conditions has revealed a number of novel and unexpected features. Here we focus on the oscillations of per and tim mRNAs […]

Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock.

Bee L, Marini S, Pontarin G, Ferraro P, Costa R, Albrecht U, Celotti L. Nucleic Acids Research Abstract The efficiency of Nucleotide Excision Repair (NER)process is crucial for maintaining genomic integrity because in many organisms, including humans, it represents the only system able to repair a wide range of DNA damage. The aim of the […]

Fly cryptochrome and the visual system.

Mazzotta G, Rossi A, Leonardi E, Mason M, Bertolucci C, Caccin L, Spolaore B, Martin AJ, Schlichting M, Grebler R, Helfrich-Förster C, Mammi S, Costa R, Tosatto SC. Proceeding of the National Academy of Sciences Abstract Cryptochromes are flavoproteins, structurally and evolutionarily related to photolyases, that are involved in the development, magnetoreception, and temporal organization […]

Drosophila clock neurons under natural conditions.

Menegazzi P, Vanin S, Yoshii T, Rieger D, Hermann C, Dusik V, Kyriacou CP, Helfrich-Förster C, Costa R. Journal of biological rhythms Abstract The circadian clock modulates the adaptive daily patterns of physiology and behavior and adjusts these rhythms to seasonal changes. Recent studies of seasonal locomotor activity patterns of wild-type and clock mutant fruit […]

Unexpected features of Drosophila circadian behavioural rhythms under natural conditions.

Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP. Nature Abstract Circadian clocks have evolved to synchronize physiology, metabolism and behaviour to the 24-h geophysical cycles of the Earth. Drosophila melanogaster’s rhythmic locomotor behaviour provides the main phenotype for the identification of higher eukaryotic clock genes. […]

Category Archives: Molecular Organism