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Category Archives: Molecular Organism

A Semi-natural Approach for Studying Seasonal Diapause in Drosophila melanogaster Reveals Robust Photoperiodicity

Nagy D.,  Andreatta G., Bastianello S., Martín Anduaga A., Mazzotta G., Kyriacou CP., Costa R. Journal of Biological Rhythms The fruit fly Drosophila melanogaster survives thermally stressful conditions in a state of reproductive dormancy (diapause), manifested by reduced metabolic activity and arrested ovarian development in females. Unlike insects that rely primarily on photoperiodic stimuli to initiate […]

Aminergic Signaling Controls Ovarian Dormancy in Drosophila

Andreatta G, Kyriacou CP, Flatt T, Costa R Scientific Reports 2018 In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. […]

Diapause in Drosophila melanogaster – photoperiodicity, cold tolerance and metabolites

Anduaga AM, Nagy D, Costa R, Kyriacou CP. Journal of Insect Physiology  2018 Unlike many insects where photoperiod per se induces diapause, reproductive arrest in Drosophila melanogaster adult females is observed at colder temperatures and can be enhanced by shorter photoperiods. Traditional experimental protocols raise flies at 25°C from the larval stage and then the adults are placed at […]

Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba

Biscontin A, Wallach T, Sales G, Grudziecki A, Janke L, Sartori E, Bertolucci C, Mazzotta G, De Pittà C, Meyer B, Kramer A, Costa R. Scientific Reports 2017 Antarctic krill (Euphausia superba) is a key species in Southern Ocean ecosystem where it plays a central role in the Antarctic food web. Available information supports the existence of an endogenous timing […]

Inverse European Latitudinal Cline at the timeless Locus of Drosophila melanogaster Reveals Selection on a Clock Gene: Population Genetics of ls-tim.

Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. J Biol Rhythms. 2017 The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may […]

Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels.

Green EW, O’Callaghan EK, Hansen CN, Bastianello S, Bhutani S, Vanin S, Armstrong JD, Costa R, Kyriacou CP. Proceeding of the National Academy of Sciences Abstract Under standard laboratory conditions of rectangular light/dark cycles and constant warm temperature, Drosophila melanogaster show bursts of morning (M) and evening (E) locomotor activity and a “siesta” in the […]