Category Archives: Liver-brain Axis

Management of the major complications of cirrhosis: Beyond guidelines

Garcia-Pagan JC, Francoz C, Montagnese S, Senzolo M, Mookerjee RP Journal of Hepatology Along with a growing understanding of the pathophysiology of cirrhosis and its complications, new therapies and management strategies have emerged in recent years. Many of these advances have helped inform the current EASL clinical practice guidelines1 on the management of some of […]

Italian association for the study of the liver position statement on SARS-CoV2 vaccination

Russo F P, Piano S, Bruno R, Burra P, Puoti M, Masarone M, Montagnese S, Ponziani F R, Petta S, Aghemo A, Italian Association for the Study of the Liver Digestive and Liver Disease The vaccination campaign against Sars-CoV-2 commenced in Italy at the end of December 2020. The first ones to receive the immunization […]

A pilot study of Golexanolone, a new GABA-A receptor modulating steroid antagonist, in patients with covert hepatic encephalopathy

Montagnese S, Lauridsen M, Vilstrup H, Zarantonello L, Lakner G, Fitilev S, Zupanets I, Kozlova I, Bunkova E, Tomasiewicz K, Berglund JE, Rorsman F, Hagström H, Kechagias S, Ocklind CE, Mauney J, Thunarf F, Mokhatarani M, Bäckström T, Doverskog M, Lins LE, Månsson M, Samuelson P, Nilsson D, Schalling M, Johansson M, Arlander E, Scharschmidt […]

Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues

Montagnese S, Bajaj JS Drugs Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormalities span daily functioning, sleep–wake cycle changes, and […]

The application of the extended Poincaré plot in the analysis of physiological variabilities

Satti R, Abid N, Bottaro M, De Rui M, Garrido M, Rauofy MR, Montagnese S, Mani AR Frontiers in Physiology The Poincaré plot is a geometrical technique used to visualize and quantify the correlation between two consecutive data points in a time-series. Since the dynamics of fluctuations in physiological rhythms exhibit long-term correlation and memory, […]

Clinical value of asterixis in 374 well-characterised patients with cirrhosis and varying degree of hepatic encephalopathy

Formentin C, Zarantonello L, Mangini C, Angeli P, Merkel C, Montagnese S Digestive and Liver Disease Current guidelines for the diagnosis of hepatic encephalopathy (HE) include the clinical sign asterixis, which defines grade II overt HE in the absence of disorientation to time [ 1 ]. Asterixis has also been used as an outcome in clinical trials […]

Blood metabolomics undercovers inflammation-associated mitochondrial dysfunction as a potentian mechanism underlying ACLF

Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot c, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin H, Hautbergue […]

A meta-analysis of magnetic resonance spectroscopy in the diagnosis of hepatic encephalopathy

Zeng G, Penninkilampi R, Chaganti J, Montagnese S, Brew BJ, Danta M Neurology Objective Various imaging modalities have been used to explore pathogenic mechanisms and stratify the severity of hepatic encephalopathy (HE). The hypothesis of this meta-analysis was that there is a progressive identifiable derangement of imaging measures using magnetic resonance spectroscopy (MRS) related to the […]

Clinical, neuropsychological and neurophysiological indices and predictors of hepatic encephalopathy (HE)

Formentin C, Zarantonello L, Mangini C, Frigo A C, Montagnese S, Merkel C Liver International Background and Aims The occurrence of overt hepatic encephalopathy (HE) marks a significant progression in the natural history of liver disease. The aims of the present study were to: 1) describe a large cohort of patients with cirrhosis in terms […]