All posts by SleepRhythm

Management of liver disease in Italy after one year of the SARS-CoV-2 pandemic: a web-based survey

Ponziani FR, Aghemo A, Cabibbo G, Masarone M, Montagnese S, Petta S, Russo FP, Lai Q; AISF COVID-19 survey group Liver International Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has severely limited the clinical activity of most hospitals around the world. A previous survey of the Italian Association for the Study of the Liver (AISF) […]

Management of the major complications of cirrhosis: Beyond guidelines

Garcia-Pagan JC, Francoz C, Montagnese S, Senzolo M, Mookerjee RP Journal of Hepatology Along with a growing understanding of the pathophysiology of cirrhosis and its complications, new therapies and management strategies have emerged in recent years. Many of these advances have helped inform the current EASL clinical practice guidelines1 on the management of some of […]

Frontiers in Chronobiology: Endogenous Clocks at the Core of Signaling Pathways in Physiology

Costa R Frontiers in Physiology Chronobiology is a relatively young and fast evolving research field, which aims at understanding the origin, the mechanisms and the prerogatives of endogenous biological clocks. The Chronobiology section of Frontiers in Physiology provides an interdisciplinary forum for the publication of research covering all aspects of the field, including molecular clock […]

Italian association for the study of the liver position statement on SARS-CoV2 vaccination

Russo F P, Piano S, Bruno R, Burra P, Puoti M, Masarone M, Montagnese S, Ponziani F R, Petta S, Aghemo A, Italian Association for the Study of the Liver Digestive and Liver Disease The vaccination campaign against Sars-CoV-2 commenced in Italy at the end of December 2020. The first ones to receive the immunization […]

A pilot study of Golexanolone, a new GABA-A receptor modulating steroid antagonist, in patients with covert hepatic encephalopathy

Montagnese S, Lauridsen M, Vilstrup H, Zarantonello L, Lakner G, Fitilev S, Zupanets I, Kozlova I, Bunkova E, Tomasiewicz K, Berglund JE, Rorsman F, Hagström H, Kechagias S, Ocklind CE, Mauney J, Thunarf F, Mokhatarani M, Bäckström T, Doverskog M, Lins LE, Månsson M, Samuelson P, Nilsson D, Schalling M, Johansson M, Arlander E, Scharschmidt […]

Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction

Peruzzo R, Corrà S, Costa R, Brischigliaro M, Varanita T, Biasutto L, Rampazzo C, Ghezzi D, Leanza L, Zoratti M, Zeviani M, De Pittà C, Viscomi C, Costa R, Szabò I Nat Commun. Mitochondrial diseases impair oxidative phosphorylation and ATP production, while effective treatment is still lacking. Defective complex III is associated with a highly variable […]

A Timely Call to Arms: COVID-19, the Circadian Clock, and Critical Care

Haspel J, Kim M, Zee P, Schwarzmeier T, Montagnese S, Panda S, Albani A, Merrow M Journal of Biological Rhythms We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19) pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we discuss aspects of SARS-CoV-2 […]

Impact of Hepatic Encephalopathy in Cirrhosis on Quality-of-Life Issues

Montagnese S, Bajaj JS Drugs Hepatic encephalopathy (HE) has a major impact on health-related quality of life (HRQOL) in patients, which has clinical and psychosocial consequences. HRQOL in cirrhosis has been measured by generic and liver-specific instruments, with most studies indicating a negative impact of HE. HRQOL abnormalities span daily functioning, sleep–wake cycle changes, and […]

The application of the extended Poincaré plot in the analysis of physiological variabilities

Satti R, Abid N, Bottaro M, De Rui M, Garrido M, Rauofy MR, Montagnese S, Mani AR Frontiers in Physiology The Poincaré plot is a geometrical technique used to visualize and quantify the correlation between two consecutive data points in a time-series. Since the dynamics of fluctuations in physiological rhythms exhibit long-term correlation and memory, […]