All posts by SleepRhythm

The application of the extended Poincaré plot in the analysis of physiological variabilities

Satti R, Abid N, Bottaro M, De Rui M, Garrido M, Rauofy MR, Montagnese S, Mani AR Frontiers in Physiology The Poincaré plot is a geometrical technique used to visualize and quantify the correlation between two consecutive data points in a time-series. Since the dynamics of fluctuations in physiological rhythms exhibit long-term correlation and memory, […]

Clinical value of asterixis in 374 well-characterised patients with cirrhosis and varying degree of hepatic encephalopathy

Formentin C, Zarantonello L, Mangini C, Angeli P, Merkel C, Montagnese S Digestive and Liver Disease Current guidelines for the diagnosis of hepatic encephalopathy (HE) include the clinical sign asterixis, which defines grade II overt HE in the absence of disorientation to time [ 1 ]. Asterixis has also been used as an outcome in clinical trials […]

Blood metabolomics undercovers inflammation-associated mitochondrial dysfunction as a potentian mechanism underlying ACLF

Moreau R, Clària J, Aguilar F, Fenaille F, Lozano JJ, Junot c, Colsch B, Caraceni P, Trebicka J, Pavesi M, Alessandria C, Nevens F, Saliba F, Welzel TM, Albillos A, Gustot T, Fernández J, Moreno C, Baldassarre M, Zaccherini G, Piano S, Montagnese S, Vargas V, Genescà J, Solà E, Bernal W, Butin H, Hautbergue […]

A meta-analysis of magnetic resonance spectroscopy in the diagnosis of hepatic encephalopathy

Zeng G, Penninkilampi R, Chaganti J, Montagnese S, Brew BJ, Danta M Neurology Objective Various imaging modalities have been used to explore pathogenic mechanisms and stratify the severity of hepatic encephalopathy (HE). The hypothesis of this meta-analysis was that there is a progressive identifiable derangement of imaging measures using magnetic resonance spectroscopy (MRS) related to the […]

Effect of Morning Light Glasses and Night Short-Wavelength Filter Glasses on Sleep-Wake Rhythmicity in Medical Inpatients

Formentin C, Carraro S, Turco M, Zarantonello L, Angeli P, Montagnese S Frontiers in physiology Sleep and circadian rhythm disorders are common amongst medical inpatients. They are caused by a mixture of factors, including noise, loss of habitual daily routines, and abnormal exposure to light, which tends to be insufficient in the day and too […]

Clinical, neuropsychological and neurophysiological indices and predictors of hepatic encephalopathy (HE)

Formentin C, Zarantonello L, Mangini C, Frigo A C, Montagnese S, Merkel C Liver International Background and Aims The occurrence of overt hepatic encephalopathy (HE) marks a significant progression in the natural history of liver disease. The aims of the present study were to: 1) describe a large cohort of patients with cirrhosis in terms […]

Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction

Von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da-Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E Life Science Alliance Aberrant mitochondrial dynamics disrupts mitochondrial function and contributes to disease conditions. A targeted RNA interference screen for […]

The role of astrocytes in generating circadian rhythmicity in health and disease

Costa R, Montagnese S Journal of Neurochemistry Evidence is accumulating that the mammalian circadian clock system is considerably more complex than previously believed, also in terms of the cell types that actually contribute to generating the oscillation within the master clock, in the suprachiasmatic nuclei of the hypothalamus. Here we review the evidence that has […]

Sleep, Circadian Rhythmicity and Response to Chronotherapy in University Students: Tips from Chronobiology Practicals

Montagnese S, Zarantonello L, Formentin C, Zancato C, Bonetto M B, Biscontin A, Cusumano P, Costa R (2021) Journal of Circadian Rhythms Chronobiology is not routinely taught to biology or medical students in most European countries. Here we present the results of the chronobiology practicals of a group of students of the University of Padova, with a […]