Gufi o allodole? Cosa sono e come funzionano gli orologi circadiani.
Costa R, Montagnese S L’orologio circadiano, che regola i ritmi sonno-veglia e altri aspetti della nostra fisiologia, si sincronizza con l’ambiente naturale che ci circonda, soprattutto per mezzo della luce del Sole. Tuttavia le nostre abitudini di vita, condizionate dall’orologio sociale, spesso confliggono con i ritmi dettati dall’orologio circadiano. Questo favorisce l’insorgenza di malattie, anche […]
The µMCTQ: An Ultra-Short Version of the Munich ChronoType Questionnaire.
Ghotbi N, Pilz LK, Winnebeck EC, Vetter C, Zerbini G, Lenssen D, Frighetto G, Salamanca M, Costa R, Montagnese S, Roenneberg T Journal of Biological Rhythms Individuals vary in how their circadian system synchronizes with the cyclic environment (zeitgeber). Assessing these differences in “phase of entrainment”-often referred to as chronotype-is an important procedure in laboratory […]
Analysis of the circadian transcriptome of the Antarctic krill Euphausia superba
Biscontin A, Martini P, Costa R, Kramer A, Meyer B, Kawaguchi S, Teschke M, De Pittà C Scientific Reports Antarctic krill (Euphausia superba) is a high latitude pelagic organism which plays a central role in the Southern ocean ecosystem. E. superba shows daily and seasonal rhythms in physiology and behaviour, which are synchronized with the environmental […]
Predictive value of induced hyperammonaemia and neuropsychiatric profiling in relation to the occurrence of post-TIPS hepatic encephalopathy
Senzolo M, Zarantonello L, Formentin C, Orlando C, Beltrame F, Vuerich A, Angeli P, Burra P, Montagnese S Metabolic Brain Disease Hepatic encephalopathy (HE) occurs in 20–50% of patients after transjugular intrahepatic portosystemic shunt (TIPS) placement. Older age, HE history and severe liver failure have all been associated with post-TIPS HE but it remains difficult to […]
Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster
Brischigliaro M, Corrà S, Tregnago C, Fernandez-Vizarra E, Zeviani M, Costa R, De Pittà C Frontiers in Physiology Cytochrome c oxidase (COX) deficiency is the biochemical hallmark of several mitochondrial disorders, including subjects affected by mutations in apoptogenic-1 (APOPT1), recently renamed as COA8 (HGNC:20492). Loss-of-function mutations are responsible for a specific infantile or childhood-onset mitochondrial leukoencephalopathy with a chronic clinical course. […]