Category Archives: Liver-brain Axis

Chaganti J, Zeng G, Patil A, Lockart I, Dellalana M, Montagnese S, Brew B, Danta M Hepatology Background: Covert hepatic encephalopathy (CHE) is clinically underrecognized. Using MRI, we explored the relationship between functional connectivity as a marker of executive dysfunction and the blood-brain barrier permeability marker KTRANS in a cross-sectional cohort of covert HE (CHE), no […]

Montagnese S, Duarte-Rojo A Hepatology Full Text

Gachon F, Bugianesi E, Castelnuovo G, Oster H, Pendergast JS, Montagnese S NPJ Metab Health Dis Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. […]

Zeng G, Krishnamurthy S, Staats Pires A, Guller A, Chaganti J, Tun N, Lockart I, Montagnese S, Brew B, Guillemin GJ, Danta M, Heng B Hepatol Commun Background: HE is a neuropsychiatric complication of liver disease characterized by systemic elevation in ammonia and proinflammatory cytokines. These neurotoxins cross the blood-brain barrier and cause neuroinflammation, which can […]

Roccarina D, Saltini D, Adotti V, Rosi M, Senzolo M, Nardelli S, Bianchini M, Biribin L, Caporali C, Margherita F, Ragozzino L, Guasconi T, Casari F, Gioia S, Campani C, Prampolini F, Ingravallo A, Gitto S, Aspite S, Arena U, Citone M, Gaggini M, Ridola L, Barbiero G, De Masi S, Riggio O, Merli M, […]

Gairing SJ, Mangini C, Zarantonello L, Jonasson E, Dobbermann H, Sultanik P, Galle PR, Labenz J, Thabut D, Marquardt JU, Bloom PP, Lauridsen MM, Montagnese S, Labenz C JHEP Rep Background & aims: Data on the association between proton pump inhibitor (PPI) use and hepatic encephalopathy (HE) are conflicting, and data from multicentre studies are […]

Sørensen M, Lauridsen MM, Montagnese S Metab Brain Dis Hepatic encephalopathy (HE) is a brain dysfunction caused by liver insufficiency with symptoms ranging from slight cognitive changes detectable only by neuropsychiatric testing to coma. Up to 60% of patients with cirrhosis have mild forms of HE and 35% will at some point experience overt HE. […]

Gairing SJ, Mangini C, Zarantonello L, Jonasson E, Danneberg S, Sultanik P, Galle PR, Gioia S, Labenz J, Lok AS, Marquardt JU, Lauridsen MM, Bloom PP, Thabut D, Nardelli S, Montagnese S, Labenz C Hepatol Commun Background: Minimal hepatic encephalopathy, defined by the portosystemic hepatic encephalopathy score (PHES), is associated with a higher risk of subsequent […]

Amodio P, Huang CH, Montagnese S Hepatology Full text

Amodio P, Montagnese S Clin Gastroenterol Hepatol Full Text