Schlichting M, Rieger D, Cusumano P, Grebler R, Costa R, Mazzotta GM, Helfrich-Förster C. Frontiers in Molecular Neuroscience Cryptochromes (CRYs) are a class of flavoproteins that sense blue light. In animals, CRYs are expressed in the eyes and in the clock neurons that control sleep/wake cycles and are implied in the generation and/or entrainment of […]
Ferrazzi E., Romualdi C., Ocello M., Frighetto G., Turco M.,Vigolo S., Fabris F., Angeli P.,Vettore G., Costa R., Montagnese S. Journal of Biological Rhythms Daylight saving time (DST) is a source of circadian disruption impinging on millions of people every year. Our aim was to assess modifications, if any, in the number, type, and outcome […]
Nagy D., Andreatta G., Bastianello S., Martín Anduaga A., Mazzotta G., Kyriacou CP., Costa R. Journal of Biological Rhythms The fruit fly Drosophila melanogaster survives thermally stressful conditions in a state of reproductive dormancy (diapause), manifested by reduced metabolic activity and arrested ovarian development in females. Unlike insects that rely primarily on photoperiodic stimuli to initiate […]
Formentin C, Garrido M, Montagnese S. Current Hepatology Reports This review presents an in-depth overview of the sleep–wake phenotype of patients with cirrhosis, together with available pharmacological and non-pharmacological treatment strategies. A set of simple, practical recommendations is also provided. The understanding of the pathophysiology of sleep disorders in this patient population has improved over the […]
Andreatta G, Kyriacou CP, Flatt T, Costa R Scientific Reports 2018 In response to adverse environmental conditions many organisms from nematodes to mammals deploy a dormancy strategy, causing states of developmental or reproductive arrest that enhance somatic maintenance and survival ability at the expense of growth or reproduction. Dormancy regulation has been studied in C. […]
Anduaga AM, Nagy D, Costa R, Kyriacou CP. Journal of Insect Physiology 2018 Unlike many insects where photoperiod per se induces diapause, reproductive arrest in Drosophila melanogaster adult females is observed at colder temperatures and can be enhanced by shorter photoperiods. Traditional experimental protocols raise flies at 25°C from the larval stage and then the adults are placed at […]
Volpato S, Montagnese S, Zanetto A, Turco M, De Rui M, Ferrarese A, Amodio P, Germani G, Senzolo M, Gambato M, Russo FP, Burra P. BMJ open gastroenterology 2017 BACKGROUND:Since direct-acting antivirals (DAAs) have been approved for the treatment of hepatitis C virus (HCV) infection, a small series of patients with new-onset neuropsychiatric alterations have been referred to us. We therefore set out to study neuropsychiatricfunction in […]
Biscontin A, Wallach T, Sales G, Grudziecki A, Janke L, Sartori E, Bertolucci C, Mazzotta G, De Pittà C, Meyer B, Kramer A, Costa R. Scientific Reports 2017 Antarctic krill (Euphausia superba) is a key species in Southern Ocean ecosystem where it plays a central role in the Antarctic food web. Available information supports the existence of an endogenous timing […]
Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. J Biol Rhythms. 2017 The spread of adaptive genetic variants in populations is a cornerstone of evolutionary theory but with relatively few biologically well-understood examples. Previous work on the ls-tim variant of timeless, which encodes the light-sensitive circadian regulator in Drosophila melanogaster, suggests that it may […]
Altered distal-proximal temperature gradient as a possible explanation for sleep-wake disturbances in cirrhotic patients. Liver International 2017 Weiss N, Attali V, Bouzbib C, Thabut D
