Stuck in time: The slow march of circadian medicine and how to speed it up
Cajochen C, Montagnese S J Sleep Res While there is considerable enthusiasm for the translational and clinical applications of chronobiology, their actual implementation is not progressing as rapidly as might be expected. Here we discuss the possibility that this may relate to a combination of conceptual, methodological, evidentiary and training challenges. These are compounded by […]
Potential bidirectional communication between the liver and the central circadian clock in MASLD
Gachon F, Bugianesi E, Castelnuovo G, Oster H, Pendergast JS, Montagnese S NPJ Metab Health Dis Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. […]
Activation of the kynurenine pathway identified in individuals with covert hepatic encephalopathy
Zeng G, Krishnamurthy S, Staats Pires A, Guller A, Chaganti J, Tun N, Lockart I, Montagnese S, Brew B, Guillemin GJ, Danta M, Heng B Hepatol Commun Background: HE is a neuropsychiatric complication of liver disease characterized by systemic elevation in ammonia and proinflammatory cytokines. These neurotoxins cross the blood-brain barrier and cause neuroinflammation, which can […]
End-procedural adherence to recommended hemodynamic targets does not improve the outcome of elective TIPS in patients with cirrhosis
Roccarina D, Saltini D, Adotti V, Rosi M, Senzolo M, Nardelli S, Bianchini M, Biribin L, Caporali C, Margherita F, Ragozzino L, Guasconi T, Casari F, Gioia S, Campani C, Prampolini F, Ingravallo A, Gitto S, Aspite S, Arena U, Citone M, Gaggini M, Ridola L, Barbiero G, De Masi S, Riggio O, Merli M, […]
Sleep timing in flies from “adolescence” to adulthood
Domenie ED, Cusumano P, Montagnese S, Costa R Fly (Austin) The aim of the present study was to assess sleep timing in Drosophila melanogaster at different ages, within the setting of an enforced schedule of varying light-dark stimuli, simulating light exposure variations between four typical office working days and one free day spent outside by a human, for a total of […]