Category Archives: Liver-brain Axis

Roccarina D, Saltini D, Mangini C, Piscopo A, Mastro A, Barbera A, Velasco Mayorga AS, Avossa A, Ragozzino L, Falcini M, Rosi M, Vozza A, Falcone G, Fanelli F, Marra F, Montagnese S, Schepis F, Vizzutti F Gastroenterology report The ageing of the cirrhotic population, together with the epidemiological shift toward metabolic dysfunction-associated steatohepatitis, is […]

Saltini D, Zarantonello L, Zanetto A, Guasconi T, Caporali C, Piscopo A, Mayorga ASV, Scoppettuolo M, Milosa F, Critelli RM, Scianò F, Casari F, Ascari F, Bianchini M, Colecchia A, Gaggini M, Vizzutti F, Montagnese S, Schepis F JHEP Reports Background & aims: Overt hepatic encephalopathy (OHE) continues to be the primary complication following transjugular […]

Lewis HM, Isherwood CM, Mani AR, Middleton B, Morgan MY, Skene DJ, Montagnese S JHEP Reports Background & aims: The aim of the present study was to evaluate the temporal dynamics of metabolites in patients with cirrhosis using hourly plasma samples collected over a full 24-hour cycle in 17 outpatients with cirrhosis of varying severity […]

Roccarina D, Saltini D, Senzolo M, Nardelli S, Rosi M, Adotti V, Bianchini M, Biribin L, Gioia S, Caporali C, Ragozzino L, Guasconi T, Falcini M, Casari F, Piscopo A, Pindozzi F, Gitto S, Aspite S, Falcone G, Ingravallo A, Gaggini M, Ferdinande K, Arena U, Merli M, Ridola L, Riggio O, Fanelli F, Mangini […]

Erminelli D, Mangini C, Gapeni D, Zarantonello L, Montagnese S Liver International Background & aims: The role of ammonia in the assessment of Overt Hepatic Encephalopathy (OHE) remains debated. The aim of the present study was to assess the time course of ammonia levels in relation to the severity and duration of an episode of OHE […]

Chaganti J, Zeng G, Patil A, Lockart I, Dellalana M, Montagnese S, Brew B, Danta M Hepatology Background: Covert hepatic encephalopathy (CHE) is clinically underrecognized. Using MRI, we explored the relationship between functional connectivity as a marker of executive dysfunction and the blood-brain barrier permeability marker KTRANS in a cross-sectional cohort of covert HE (CHE), no […]

Montagnese S, Duarte-Rojo A Hepatology Full Text

Gachon F, Bugianesi E, Castelnuovo G, Oster H, Pendergast JS, Montagnese S NPJ Metab Health Dis Most aspects of physiology and behaviour fluctuate every 24 h in mammals. These circadian rhythms are orchestrated by an autonomous central clock located in the suprachiasmatic nuclei that coordinates the timing of cellular clocks in tissues throughout the body. […]

Zeng G, Krishnamurthy S, Staats Pires A, Guller A, Chaganti J, Tun N, Lockart I, Montagnese S, Brew B, Guillemin GJ, Danta M, Heng B Hepatol Commun Background: HE is a neuropsychiatric complication of liver disease characterized by systemic elevation in ammonia and proinflammatory cytokines. These neurotoxins cross the blood-brain barrier and cause neuroinflammation, which can […]

Roccarina D, Saltini D, Adotti V, Rosi M, Senzolo M, Nardelli S, Bianchini M, Biribin L, Caporali C, Margherita F, Ragozzino L, Guasconi T, Casari F, Gioia S, Campani C, Prampolini F, Ingravallo A, Gitto S, Aspite S, Arena U, Citone M, Gaggini M, Ridola L, Barbiero G, De Masi S, Riggio O, Merli M, […]