Epigenetic modifications induced by chronic disruption of the circadian clock in Drosophila

Identification of pathways modulating sleep duration, from genomics to transcriptomics

Functional and molecular characterization of genes involved in mitochondrial diseases in model organisms

Chronotherapy for sleep-wake disturbances in patients with liver disease and dementing disorders

Ad-hoc diagnostic and treatment protocols for medical patients with circadian disorders (on a collaborative basis with visiting Professor Till Roenneberg)

Hospitalization-related sleep-wake disturbances

Genetic basis of diurnal preference and fluctuations in vigilance and mood over the 24 hours

SLEEP & RHYTMS IN MEDICINE COURSE for medical students.

Students learn a set of core concepts and then attend a series of practicals in which they are welcome to test sleep-wake questionnaires, actigraphs, a polysomnography machine, temperature sensors and other relevant tools. The course started in academic year 2015-2016 and was opened by Professor Debra Skene (UK), current President of European Biological Rhythms Society.

NEUROBIOLOGY study module for the Masters in Molecular Biology.

Students learn about the neurogenetic bases of circadian rhythmicity, and the functional organization of the biological clock in Drosophila melanogaster and in mammals. In addition, they learn about mechanisms of clock synchronisation and about the consequences of desynchronisation/misalignment. Practicals include genotyping for clock gene polymorphisms, definition of chronotype and direct experience of the effects of morning light administration on sleep-wake patterns and melatonin urinary metabolites.