Founders

costa r foto

Prof. Rodolfo Costa

Neurogenetics and Chronobiology
The unit has a longstanding research interest in circadian chronobiology (i.e. the study of biological events as a function of time and in terms of their rhythms). Our work has focused on the genetic, molecular and behavioural analysis of the circadian clock in the model organism Drosophila melanogaster, as well as other organisms such as the Antartic krill. More recently, our research interests have extended to the circadian biology of humans. In addition, we are active in the field of functional genomics, and use Drosophila as a model for the study of orthologs of human genes involved in mitochondrial pathology.

Biography

Rodolfo Costa holds the Chair of Genetics at the University of Padova, in Italy. For several years, his research focus has been the study of the biological clock in different organisms, in terms of its genetic/molecular features and its physiological and behavioural correlates. He is also active in the field of functional genomics, utilizing the fruit fly (Drosophila melanogaster) as a model for the study of homologues of human genes implicated in mitochondrial diseases. His research has been funded by the European Union (CEC Science Plan; EC-Biotechnology Programme; EU 6th Framework Programme – EUCLOCK; Marie Curie FP7 ITN – INsecTIME), the Helmholtz Centre for Environmental Research – POLARTIME, the Italian Ministry of Education, the Italian Ministry of Agricultural Policies, the Italian Space Agency, the National Research Council of Italy (CNR – EPIGEN), the University of Padova, and the CaRiPaRo and Telethon foundations. He has been actively involved in major popular sciences initiatives including the Genova Science Festival and the Padova Galileo book award. He is the current President of the Italian Association for Genetics (AGI), and a member of the European Biological Rhythm Society (EBRS) and the American Society for Research on Biological Rhythms (SRBR). He also serves as the Editor in Chief of the section Chronobiology of Frontiers in Physiology.

Publications

Nagy D, Cusumano P, Andreatta G, Anduaga AM, Hermann-Luibl C, Reinhard N,Gesto J, Wegener C, Mazzotta G, Rosato E, Kyriacou CP, Helfrich-Förster C, Costa R (2019). Peptidergic signaling from clock neurons regulates reproductive dormancy in Drosophila melanogaster. PLos Genetics

von Stockum S, Sanchez-Martinez A, Corrà S, Chakraborty J, Marchesan E, Locatello L, Da-Rè C, Cusumano P, Caicci F, Ferrari V, Costa R, Bubacco L, Rasotto MB, Szabo I, Whitworth AJ, Scorrano L, Ziviani E. (2019) Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction. Life Science Alliance

Cusumano P,  Damulewicz M, Carbognin E, Caccin L, Puricella A, Specchia V, Bozzetti MP, Costa R, Mazzotta GM. (2019) The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation in Drosophila melanogaster. Frontiers in Physiology

Andreatta G, Kyriacou CP, Flatt T, Costa R. (2018) Aminergic signaling controls ovarian dormancy in Drosophila. Scientific Reports

Turco M, Cazzagon N, Franceschet I, Formentin C, Frighetto G, Giordani F, Cellini N, Mazzotta G, Costa R, Middleton B, Skene DJ, Floreani A, Montagnese S. (2018) Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study. Frontiers in Physiology

 

 

Mazzotta GM, Bellanda M, Minervini G, Damulewicz M, Cusumano P, Aufiero S, Stefani M, Zambelli B, Mammi S, Costa R, Tosatto SCE. (2018) Calmodulin enhances cryptochrome binding to INAD in Drosophila photoreceptors. Frontiers in Molecular Neuroscience

Schlichting M, Rieger D, Cusumano P, Grebler R, Costa R, Mazzotta GM, Helfrich-Förster C. Cryptochrome interacts with actin and enhances eye-mediated light sensitivity of the circadian clock in Drosophila melanogaster. (2018) Frontiers in Molecular Neuroscience

Nagy D, Andreatta G, Bastianello S, Anduaga AM, Mazzotta GM, Kyriacou CP, Costa R. (2018) A semi-natural approach for studying seasonal diapause in Drosophila melanogaster reveals robust photoperiodicity. Journal of Biological Rhythms

Zonato V, Vanin S, Costa R, Tauber E, Kyriacou CP. (2018) Inverse European latitudinal cline at the timeless locus of Drosophila melanogaster reveals selection on a clock gene: population genetics of ls-tim. Journal of Biological Rhythms

Cusumano P, Biscontin A, Sandrelli F, Mazzotta GM, Tregnago C, De Pittà C, Costa R. (2018) Modulation of miR-210 alters phasing of circadian locomotor activity and impairs projections of PDF clock neurons in Drosophila melanogaster. PLoS Genetics

Allebrandt KV, Teder-Laving M, Cusumano P, Frishman G, Levandovski R, Ruepp A, Hidalgo MPL, Costa R, Metspalu A, Roenneberg T, De Pittà C. (2017) Identifying pathways modulating sleep duration: From genomics to transcriptomics. Scientific Reports

Turco M, Biscontin A, Corrias M, Caccin L, Bano M, Chiaromanni F, Salamanca M, Mattei D, Salvoro C, Mazzotta G, De Pittà C, Middleton B, Skene DJ, Montagnese S, Costa R. (2017) Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3. Scientific Reports

Biscontin A, Wallach T, Sales G, Grudziecki A, Janke L, Sartori E, Bertolucci C, Mazzotta GM, De Pittà C, Meyer B, Kramer A, Costa R. (2017) Functional characterization of the circadian clock in the Antarctic krill, Euphausia superba. Scientific Reports

Marini S, Santangeli O, Saarelainen P, Middleton B, Chowdhury N, Skene DJ, Costa R, Porkka-Heiskanen T, Montagnese S. (2017) Abnormalities in the Polysomnographic, Adenosine and Metabolic Response to Sleep Deprivation in an Animal Model of Hyperammonemia. Frontiers in Physiology

Damulewicz M, Mazzotta GM, Sartori E, Rosato E, Costa R, Pyza EM. (2017) Cryptochrome is a regulator of synaptic plasticity in the visual system of Drosophila melanogaster. Frontiers in Molecular Neuroscience

Sales G, Deagle BE, Calura E, Martini P, Biscontin A, De Pittà C, Kawaguchi S, Romualdi C, Meyer B, Costa R, Jarman S. (2017) KrillDB: A de novo transcriptome database for the Antarctic krill (Euphausia superba). PLoS ONE

Schiesari L, Andreatta G, Kyriacou CP, O’Connor MB, Costa R. The insulin-like proteins dILPs-2/5 determine diapause inducibility in Drosophila. (2016) PloS ONE

Biscontin A, Frigato E, Sales G, Mazzotta GM, Teschke M, De Pittà C, Jarman S, Meyer B, Costa R, Bertolucci C. (2016) The opsin repertoire of the Antarctic krill Euphausia superba. Marine genomics

Turco M, Corrias M, Chiaromanni F, Bano M, Salamanca M, Caccin L, Merkel C, Amodio P, Romualdi C, De Pittà C, Costa R, Montagnese S. (2015) The self-morningness/eveningness (Self-ME): An extremely concise and totally subjective assessment of diurnal preference. Chronobiology International

Green EW, O’Callaghan EK, Hansen CN, Bastianello S, Bhutani S, Vanin S, Armstrong JD, Costa R, Kyriacou CP. (2015) Drosophila circadian rhythms in seminatural environments: Summer afternoon component is not an artifact and requires TrpA1 channels. PNAS

Bee L, Nasca A, Zanolini A, Cendron F, D’Adamo P, Costa R, Lamperti C, Celotti L, Ghezzi D, Zeviani M. (2015) A nonsense mutation of human XRCC4 is associated with adult-onset progressive encephalocardiomyopathy. EMBO molecular medicine

Bee L, Marini S, Pontarin G, Ferraro P, Costa R, Albrecht U, Celotti L. (2015) Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock. Nucleic acids research

Montelli S, Mazzotta GM, Vanin S, Caccin L, Corrà S, De Pittà C, Boothroyd C, Green EW, Kyriacou CP, Costa R. Period and timeless mRNA splicing profiles under natural conditions in Drosophila melanogaster. Journal of Biological Rhythms

Minervini  G, Mazzotta GM, Masiero A, Sartori E, Corrà S, Potenza E, Costa R, Tosatto SCE. (2015) Isoform-specific interactions of the von Hippel-Lindau tumor suppressor protein. Scientific reports

Green EW, O’Callaghan EK, Pegoraro M, Armstrong JD, Costa R, Kyriacou CP. (2015) Genetic analysis of Drosophila circadian behavior in seminatural conditions. Methods in Enzymology

Von Stockum S, Giorgio V, Trevisan E, Lippe G, Glick GD, Forte MA, DaRè C, Checchetto V,Mazzotta GM,  Costa R, Szabò I, Bernardi P. (2015) F-ATPase of Drosophila melanogaster forms 53-picosiemen (53-pS) channels responsible for mitochondrial Ca2+-induced Ca2+ release. Journal of Biological Chemistry

Bano M, Chiaromanni F, Corrias M, Turco M, De Rui M, Amodio P, Merkel C, Gatta A, Mazzotta G, Costa R, Montagnese S. (2014) The influence of environmental factors on sleep quality in hospitalized medical patients. Frontiers in Neurology

Da-Rè C, von Stockum S, Biscontin A, Millino C, Cisotto P, Zordan MA, Zeviani M, Bernardi P, De Pittà C, Costa R. (2014) Leigh syndrome in Drosophila melanogaster: morphological and biochemical characterization of Surf1 post-transcriptional silencing. The Journal of biological chemistry.

Masiero A, Aufiero S, Minervini G, Moro S, Costa R, Tosatto SCE. (2014) Evaluation of the steric impact of flavin adenin dinucleotide in Drosophila melanogaster cryptochrome function. Biochemical and biophysical research communications

Da-Ré C, De Pittà C, Zordan MA, Teza G, Nestola F, Zeviani M, Costa R, Bernardi P. UCP4C mediates uncoupled respiration in larvae of Drosophila melanogaster. EMBO reports

Montagnese S, De Pittà C, De Rui M, Corrias M, Turco M, Merkel C, Amodio P, Costa R, Skene DJ, Gatta A. (2014) Sleep-wake abnormalities in patients with cirrhosis. Hepatology

Da-Rè C, Franzolin E, Biscontin A, Piazzesi A, Pacchioni B, Gagliani MC, Mazzotta GM, Tacchetti C, Zordan MA, Zeviani M, Bernardi P, Bianchi V, De Pittà C, Costa R. (2014) Functional characterization of drim2, the Drosophila melanogaster homolog of the yeast mitochondrial deoxynucleotide transporter. The Journal of biological chemistry

Menegazzi P, Vanin S, Yoshii T, Rieger D, Hermann C, Dusik V, Kyriacou CP, Helfrich-Förster C, Costa R. (2013) Drosophila clock neurons under natural conditions. Journal of Biological Rhythms

Mazzotta GM, Rossi A, Leonardi E, Mason M, Bertolucci C, Caccin L, Spolaore B, Martin AJM, Schlichting M, Grebler R, Helfrich-Förster C, Mammi S, Costa R, Tosatto SCE. (2013) Fly cryptochrome and the visual system. PNAS

De Pittà C, Biscontin A, Albiero A, Sales G, Millino C, Mazzotta GM, Bertolucci C, Costa R. (2013) The antarctic krill Euphausia superba shows diurnal cycles of transcription under natural conditions. PloS ONE

Costa R, Stanewsky R. (2013) When population and evolutionary genetics met behaviour. Memórias do Instituto Oswaldo Cruz

Baggio F,  Bozzato A, Benna C, Leonardi E, Romoli O, Cognolato M, Tosatto SCE, Costa R, Sandrelli F. (2013) 2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity. PLoS ONE

Kauranen H, Menegazzi P, Costa R, Helfrich-Förster C, Kankainen A, Hoikkala A. (2012) Flies in the north: locomotor behavior and clock neuron organization of Drosophila montana. Journal of biological rhythms

Vanin S, Bhutani S, Montelli S, Menegazzi P, Green EW, Pegoraro M, Sandrelli F, Costa R, Kyriacou CP. (2012) Unexpected features of Drosophila circadian behavioural rhythms under natural conditions. Nature

Schiesari L, Kyriacou CP, Costa R. (2011) The hormonal and circadian basis for insect photoperiodic timing. FEBS letters

Ghezzi D, Arzuffi P, Zordan MA, Da-Rè C, Lamperti C, Benna C, D’Adamo P, Diodato D, Costa R, Mariotti C, Uziel G, Smiderle C, Zeviani M. (2011) Mutations in TTC19 cause mitochondrial complex III deficiency and neurological impairment in humans and flies. Nature genetics

Mazzotta GM, De Pittà C, Benna C, Tosatto SCE, Lanfranchi G, Bertolucci C, Costa R. (2010) A cry from the krill. Chronobiology international

Benna C, Bonaccorsi S, Wülbeck C, Helfrich-Förster C, Gatti M, Kyriacou CP, Costa R, Sandrelli F. (2010) Drosophila timeless2 is required for chromosome stability and circadian photoreception. Current biology

Yoshii T, Vanin S, Costa R, Helfrich-Förster C. (2009) Synergic entrainment of Drosophila’s circadian clock by light and temperature. Journal of biological rhythms

Benna C, Peron S, Rizzo G, Faulkner G, Megighian A, Perini G, Tognon G, Valle G, Reggiani C, Costa R, Zordan MA. (2009) Post-transcriptional silencing of the Drosophila homolog of human ZASP: a molecular and functional analysis. Cell and tissue research

Fernandez-Ayala DJ, Sanz A, Vartiainen S, Kemppainen KK, Babusiak M, Mustalahti E, Costa R, Tuomela T, Zeviani M, Chung J, O’Dell KM, Rustin P, Jacobs HT. (2009) Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation.  Cell metabolism

Cruciani F, Trombetta B, Labuda D, Modiano D, Torroni A, Costa R, Scozzari R. (2008) Genetic diversity patterns at the human clock gene period 2 are suggestive of population-specific positive selection.  European journal of human genetics

Sandrelli F, Costa R, Kyriacou CP, Rosato E. (2008) Comparative analysis of circadian clock genes in insects. Insect molecular biology

Kyriacou CP, Peixoto AA, Sandrelli F, Costa R, Tauber E. (2008) Clines in clock genes: fine-tuning circadian rhythms to the environment. Trends in genetics

Specchia V, Benna C, Mazzotta GM, Piccin A, Zordan MA, Costa R, Bozzetti MP. (2008) aubergine gene overexpression in somatic tissues of aubergine(sting) mutants interferes with the RNAi pathway of a yellow hairpin dsRNA in Drosophila melanogaster.Genetics

De Pittà C, Bertolucci C, Mazzotta GM, Bernante F, Rizzo G, De Nardi B, Pallavicini A, Lanfranchi G, Costa R. (2008) Systematic sequencing of mRNA from the Antarctic krill (Euphausia superba) and first tissue specific transcriptional signature. BMC genomics

Codd V, Dolezel D, Stehlik J, Piccin A, Garner KJ, Racey SN, Straatman KR, Louis EJ, Costa R, Sauman I, Kyriacou CP, Rosato E. (2007) Circadian rhythm gene regulation in the housefly Musca domestica. Genetics

Kyriacou CP, Peixoto AA, Costa R  (2007) A cline in the Drosophila melanogaster period gene in Australia: neither down nor under. Journal of evolutionary biology

Tauber E, Zordan M, Sandrelli F, Pegoraro M, Osterwalder N, Breda C, Daga A, Selmin A, Monger K, Benna C, Rosato E, Kyriacou CP, Costa R. (2007) Natural selection favors a newly derived timeless allele in Drosophila melanogaster. Science (New York, N.Y.)

Sandrelli F, Tauber E, Pegoraro M, Mazzotta G, Cisotto P, Landskron J, Stanewsky R, Piccin A, Rosato E, Zordan M, Costa R, Kyriacou CP. (2007) A molecular basis for natural selection at the timeless locus in Drosophila melanogaster. Science (New York, N.Y.)

Hemsley MJ, Mazzotta GM, Mason M, Dissel S, Toppo S, Pagano MA, Sandrelli F, Meggio F, Rosato E, Costa R, Tosatto SC. (2007) Linear motifs in the C-terminus of D. melanogaster cryptochrome. Biochemical and biophysical research communications

Sandrelli F, Cappellozza S, Benna C, Saviane A, Mastella A, Mazzotta GM, Moreau S, Pegoraro M, Piccin A, Zordan MA, Cappellozza L, Kyriacou CP, Costa R. (2007) Phenotypic effects induced by knock-down of the period clock gene in Bombyx mori. Genetical Research

Sawyer LA, Sandrelli F, Pasetto C, Peixoto AA, Rosato E, Costa R, Kyriacou CP.(2007) The period gene Thr-Gly polymorphism in Australian and African Drosophila melanogaster populations: implications for selection.Genetics

Semplicini A, Lenzini L, Sartori M, Papparella I, Calò LA, Pagnin E, Strapazzon G, Benna C, Costa R, Avogaro A, Ceolotto G, Pessina AC. (2007) Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II. Journal of hypertension

Mocellin S, Costa R, Nitti D. (2006) RNA interference: ready to silence cancer? Journal of molecular medicine (Berlin, Germany)

Zordan MA, Cisotto P, Benna C, Agostino A, Rizzo G, Piccin A, Pegoraro M, Sandrelli F, Perini G, Tognon G, De Caro R, Peron S, Kronniè TT, Megighian A, Reggiani C, Zeviani M, Costa R. (2006) Post-transcriptional silencing and functional characterization of the Drosophila melanogaster homolog of human Surf1.  Genetics

Mazzotta GM, Sandrelli F, Zordan MA, Mason M, Benna C, Cisotto P, Rosato E, Kyriacou CP, Costa R. (2005) The clock gene period in the medfly Ceratitis capitata.  Genetical research

Zordan MA, Massironi M, Ducato MG, Te Kronnie G, Costa R, Reggiani C, Chagneau C, Martin JR, Megighian A. (2005) Drosophila CAKI/CMG protein, a homolog of human CASK, is essential for regulation of neurotransmitter vesicle release.  Journal of neurophysiology

Dissel S, Codd V, Fedic R, Garner KJ, Costa R, Kyriacou CP, Rosato E. (2004) A constitutively active cryptochrome in Drosophila melanogaster. Nature neuroscience

Rogers AS, Rosato E, Costa R, Kyriacou CP. (2004) Molecular analysis of circadian clocks in Drosophila simulans. Genetica

Rogers AS, Escher SA, Pasetto C, Rosato E, Costa R, Kyriacou CP. (2004) A mutation in Drosophila simulans that lengthens the circadian period of locomotor activity. Genetica

Zordan M, Sandrelli F, Costa R. (2003) A concise overview of circadian timing in Drosophila. Frontiers in bioscience

Tauber E, Roe H, Costa R, Hennessy JM, Kyriacou CP. (2003) Temporal mating isolation driven by a behavioral gene in Drosophila.  Current biology

Tauber E, Roe H, Costa R, Hennessy JM, Kyriacou CP. (2003) Temporal mating isolation driven a behavioral gene in Drosophila.  Current Biology

Vodovar N, Clayton JD, Costa R, Odell M, Kyriacou CP. (2002) The Drosophila clock protein Timeless is a member of the Arm/HEAT family. Current biology

Calò L, Ceolotto G, Milani M, Pagnin E, van den Heuvel LP, Sartori M, Davis PA, Costa R, Semplicini A. (2001) Abnormalities of Gq-mediated cell signaling in Bartter and Gitelman syndromes.  Kidney international

Calò L, Milani M, Pagnin E, Davis P, Piccin A, Costa R, Plebani M, Semplicini A.(2001) Analysis of Gq protein alpha subunit mRNA expression in human monocytes: relevance of the purification step.  Clinica chimica acta

Rosato E, Codd V, Mazzotta G, Piccin A, Zordan M, Costa R, Kyriacou CP. (2001) Light-dependent interaction between Drosophila CRY and the clock protein PER mediated by the carboxy terminus of CRY. Current biology

Piccin A, Salameh A, Benna C, Sandrelli F, Mazzotta G, Zordan M, Rosato E, Kyriacou CP, Costa R. (2001) Efficient and heritable functional knock-out of an adult phenotype in Drosophila using a GAL4-driven hairpin RNA incorporating a heterologous spacer. Nucleic acids research

Campesan S, Chalmers D, Sandrelli F, Megighian A, Peixoto AA, Costa R, Kyriacou CP. (2001) Comparative analysis of the nonA region in Drosophila identifies a highly diverged 5′ gene that may constrain nonA promoter evolution. Genetics

Sandrelli F, Campesan S, Rossetto M, Benna C, Zieger E, Megighian A, Couchman M, Kyriacou C, Costa R. (2001) Molecular Dissection of the 5′ Region of no-on-transientA of Drosophila melanogaster Reveals cis-Regulation by Adjacent dGpi1 Sequences. Genetics

Zordan M, Osterwalder N, Rosato E, Costa R. (2001)Extra ocular photic entrainment in Drosophila melanogaster. Journal of neurogenetics

Megighian A, Zordan M, Costa R.(2001) Giant neuron pathway neurophysiological activity in per(0) mutants of Drosophila melanogaster Journal of neurogenetics

Piccin A, Salameh A, Benna C, Sandrelli F, Mazzotta G, Zordan M, Rosato E, Kyriacou CP, Costa R. (2001) Efficient and heritable functional knock-out of an adult phenotype in Drosophila using a GAL4-driven hairpin RNA incorporating a heterologous spacer. Nucleic acids research

Peixoto AA, Costa R, Hall JC. (2001) Molecular and behavioral analysis of sex-linked courtship song variation in a natural population of Drosophila melanogaster. Journal of neurogenetics

Benna C, Scannapieco P, Piccin A, Sandrelli F, Zordan M, Rosato E, Kyriacou CP, Valle G, Costa R. (2000) A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Current biology

Zordan M, Costa R, Macino G, Fukuhara C, Tosini G. (2000) Circadian clocks: what makes them tick?  Chronobiology international

Piccin A, Couchman M, Clayton JD, Chalmers D, Costa R, Kyriacou CP. (2000) The clock gene period of the housefly, Musca domestica, rescues behavioral rhythmicity in Drosophila melanogaster. Evidence for intermolecular coevolution? Genetics

Benna C, Scannapieco P, Piccin A, Sandrelli F, Zordan M, Rosato E, Kyriacou CP, Valle G, Costa R. (2000) A second timeless gene in Drosophila shares greater sequence similarity with mammalian tim. Current Biology

Guantieri V, Pepe A, Zordan M, Kyriacou CP, Costa R, Tamburro AM. (2000) Different period gene repeats take ‘turns’ at fine-tuning the circadian clock. Proceedings Biological Sciences

Costa R, Kyriacou CP. (1998) Functional and evolutionary implications of natural variation in clock genes. Current opinion in neurobiology

Peixoto AA, Hennessy JM, Townson I, Hasan G, Rosbash M, Costa R, Kyriacou CP. (1998) Molecular coevolution within a Drosophila clock gene. Proceedings of the National Academy of Sciences of the United States of America

Sawyer LA, Hennessy JM, Peixoto AA, Rosato E, Parkinson H, Costa R, Kyriacou CP. (1997) Natural variation in a Drosophila clock gene and temperature compensation. Science

Verri T, Argenton F, Tomanin R, Scarpa M, Storelli C, Costa R, Colombo L, Bortolussi M. (1997) The bacteriophage T7 binary system activates transient transgene expression in zebrafish (Danio rerio) embryos.  Biochemical and biophysical research communications

Rosato E, Peixoto AA, Costa R, Kyriacou CP. (1997) Linkage disequilibrium, mutational analysis and natural selection in the repetitive region of the clock gene, period, in Drosophila melanogaster.  Genetical research

Rosato E, Trevisan A, Sandrelli F, Zordan M, Kyriacou CP, Costa R. (1997) Conceptual translation of timeless reveals alternative initiating methionines in Drosophila. Nucleic Acids Research

Rosato E, Peixoto AA, Gallippi A, Kyriacou CP, Costa R. (1996) Mutational mechanisms, phylogeny, and evolution of a repetitive region within a clock gene of Drosophila melanogaster.  Journal of molecular evolution

Castiglione-Morelli MA, Guantieri V, Villani V, Kyriacou CP, Costa R, Tamburro AM.(1995) Conformational study of the Thr-Gly repeat in the Drosophila clock protein, PERIOD.  Proceedings Biological sciences

Nielsen J, Peixoto AA, Piccin A, Costa R, Kyriacou CP, Chalmers D. (1994) Big flies, small repeats: the “Thr-Gly” region of the period gene in Diptera. Molecular biology and evolution

Rosato E, Peixoto AA, Barbujani G, Costa R, Kyriacou CP. (1994) Molecular polymorphism in the period gene of Drosophila simulans.  Genetics

Zordan M, Osti M, Pesce M, Costa R. (1994) Chloral hydrate is recombinogenic in the wing spot test in Drosophila melanogaster.  Mutation research

Zordan M, Osti M, Pavanello S, Costa R, Levis AG. (1994) Relationship between benzo(a)pyrene-DNA adducts and somatic mutation and recombination in Drosophila melanogaster.Environmental and molecular mutagenesis

Peixoto AA, Campesan S, Costa R, Kyriacou CP. (1993) Molecular evolution of a repetitive region within the per gene of Drosophila. Molecular biology and evolution

Peixoto AA, Costa R, Wheeler DA, Hall JC, Kyriacou CP. (1992) Evolution of the threonine-glycine repeat region of the period gene in the melanogaster species subgroup of Drosophila. Journal Molecular Evolution

Costa R, Peixoto AA, Barbujani G, Kyriacou CP. (1992) A latitudinal cline in a Drosophila clock gene. Proceedings Biological sciences

Zordan M, Graf U, Singer D, Beltrame C, Dalla Valle L, Osti M, Costa R, Levis AG. (1991) The genotoxicity of nitrilotriacetic acid (NTA) in a somatic mutation and recombination test in Drosophila melanogaster. Mutation research

Costa R, Peixoto AA, Thackeray JR, Dalgleish R, Kyriacou CP. (1991) Length polymorphism in the threonine-glycine-encoding repeat region of the period gene in Drosophila. Journal of molecular evolution

Zordan M, Costa R, Levis AG. (1991) Perspectives in the use of Drosophila melanogaster in genotoxicity testing. Progress in clinical and biological research

Zordan M, Russo A, Costa R, Bianco N, Beltrame C, Levis AG. (1990) A concerted approach to the study of the aneuploidogenic properties of two chelating agents (EDTA and NTA) in the germ and somatic cell lines of Drosophila and the mouse.  Environmental and molecular mutagenesis

Gava CG , Costa R, Zordan M, Venier P, Bianchi A, Levis AG. (1998) Induction of gene mutations in salmonella and drosophila by soluble Cr(Vi) compounds: Synergistic effects of nitrilotriacetic acid. Toxicological & Environmental Chemistry

Costa R, Zonta LA, Osti M, Jayakar SD (1989). Genetic analysis of adult locomotor activity in drosophila melanogaster.  Heredity

Costa R, Strolego G, Levis AG. (1988) Mutagenicity of lead chromate in Drosophila melanogaster in the presence of nitrilotriacetic acid (NTA).  Mutation research

Costa R, Russo A, Zordan M, Pacchierotti F, Tavella A, Levis AG.(1988)Nitrilotriacetic acid (NTA) induces aneuploidy in Drosophila and mouse germ-line cells. Environmental and molecular mutagenesis

Costa R, Nigro L, Cambissa V,  Jayakar D,   Zonta L, Beardmore JA. (1985) Selection in highly inbred populations of Drosophila melanogaster polymorphic at a single locus.  Heredity

Costa R, Nigro L, Danieli GA.(1983) Esterase-6 allozymes: biochemical studies of two common and one rare variant in Drosophila melanogaster. Biochemical genetics